Restricted Solution Set

Hello All,

I'm trying to fit parameters to my model (using some known experimental values), the thing is that it's not computationally cheap to evaluate. I have a voltage source and all the model does is to calculate the distribution of the potential in space. I was wondering if it's possible to restrict the calculations to only solving at the points where the experimental values are defined, and if that would even speed it up to any degree?

Thanks,
Aaron R. Shifman